The men reportedly used terrible language, threatened cabin crew and even sexually harassed crew in front of holiday-bound families with young children.
The BBC said that the men became disruptive during flight FF694 on Saturday.
They had started causing problems before the flight took off, and police even went on board at Prestwick to warn them about their behaviour. Spanish police boarded the flight when it landed in Ibiza, and it is thought that five men were removed.
But as the Ryanair flight became airborne, the drunken rampage escalated. People were shouting and jumping on seats say the press reports. Passengers were even forced to use the front toilets as the group took over the back of the plane and made it a no-go area.
One passenger Fiona Black, 58, from Ayr, said the flight was the worst she had ever been on. She told the Daily Record: "It was awful. There was one guy in particular who was singling out the stewardesses. "He was walking behind her when she was doing the drinks trolley and was pretending to have sex with her."
She added that one male flight attendant tried to defend a co-worker and "it seemed like he was going to be punched".
Ryanair's head of communications Robin Kiely told Aol Travel: "Ryanair crew operating flight FR694 requested police assistance on arrival at Ibiza airport after a group of passengers became disruptive in-flight.
"Police removed and detained a number of individuals from the aircraft before other passengers disembarked.
"Ryanair sincerely apologises to other passengers for any inconvenience caused but the safety of our passengers, crew and aircraft is our number one priority. This is now a matter for the police."
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